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Two Fully Referenced Alleles
Exon 2 Exon 3 Exon 4
Exon 2 Exon 3 Exon 4
full270+276+276=822
part0+0+0=0
unreferenced0+0+0=0
One Partially Referenced Allele
Exon 2 Exon 3 Exon 4
Exon 2 Exon 3 Exon 4
full270+276+0= 546
part0+0+276= 276
unreferenced0+0+0=0
Two Partially Referenced Alleles
Exon 2 Exon 3 Exon 4
Exon 2 Exon 3 Exon 4
full270+276+0=546
part0+0+0=0
unreferenced0+0+ 276=276
Matching with Partially Referenced Alleles
The observed sequence covers exons 2, 3 and 4.
Observed Exon 2 Exon 3 Y
There are four alleles in the library that match the observed sequence in exons 2 and 3.
Allele X*01 Exon 2 Exon 3 C
Allele X*02 Exon 2 Exon 3 G
Allele X*03 Exon 2 Exon 3 ?
Allele X*04 Exon 2 Exon 3 ?
We can reject some of the combinations by looking at the exon 4 sequence.
X*01 + X*02 Exon 2 Exon 3 C + G = S
This combination will give C + G = S in Exon 4 so we can reject it because the observed sequence is Y.
X*01 + X*03 Exon 2 Exon 3 C + ? = C, S, or Y
This combination might give C, S or Y in Exon 4. We cannot reject it because it might be a match.
X*02 + X*03 Exon 2 Exon 3 G + ? = G, S, or K
This combination might give G, S or K in Exon 4. We can reject it because it cannot give a Y.
X*03 + X*04 Exon 2 Exon 3 ?
We don't know anything about exon 4. We cannot reject this allele pair because it might give a Y.